Apply for PhD Positions or Postdocs in single-molecule studies of chromatin replication (Paid opportunity)

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Description

PhD Positions or Postdocs in Single-molecule Studies of Chromatin Replication

In recent years, it has become possible to reconstitute the activity of eukaryotic replisome in biochemical experiments, including on chromatin substrates. Here, you will take on the exciting challenge of understanding the dynamics of chromatin replication by studying this key biological process at the single-molecule level. This includes examining the advance of the replisome in the face of nucleosomes, and the transfer and loading of nucleosomes onto the daughter strands by histone chaperones, among other topics. To do this, you will utilise our fluorescence imaging and single-molecule force spectroscopy systems. You will be involved in the purification and labelling of proteins as necessary. You will analyse resulting datasets using biophysical modelling, and discuss extensively with collaborators in the Diffley Lab (Francis Crick institute) in the areas of molecular biology and biochemistry.

Opportunity focus area:
Molecular genetics

Specialties

Biology, Natural Sciences & Mathematics

Eligibilities

Not Specified

Gender

Nationality

Algeria, Bahrain, Comoros, Cyprus, Djibouti, Egypt, Iraq, Jordan, Kuwait, Lebanon, Libya, Mauritania, Morocco, Oman, Palestine, Qatar, Saudi Arabia, Somalia, South Sudan, Sudan, Syria, Tunisia, Turkey, UAE, Yemen

Required Languages

Other Requirements

What they are looking for?

They are looking to hire outstanding experimentalists for this exciting ERC-funded collaborative project at the interface of biochemistry and biophysics. They have openings for PhD students or post-doctoral researchers keen to participate in probing different aspects of chromatin replication from a mechanistic perspective.

Duties

As a researcher on this project, you will be responsible for planning and carrying out experiments and for analysing data. You will be expected to contribute to the interpretation of biophysical experiments on the basis of detailed analysis, to acquire an in-depth knowledge of the background literature, and to integrate the results of your data with those of ongoing molecular biology and biochemistry experiments in the field.

Necessity

A strong background in biophysics or biochemistry is a necessity.

Benefits

Salary

For a PhD: TU Delft offers PhD-candidates a 4-year contract, with an official go/no go progress assessment after one year. Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities, increasing from € 2395 per month in the first year to € 3061 in the fourth year.

Local Transportation

For international applicants they offer the Coming to Delft Service and Partner Career Advice to assist you with your relocation.

Others

The TU Delft offers a customisable compensation package, discounts on health insurance and sport memberships, and a monthly work costs contribution.

Cover Tuition Fees

As a PhD candidate you will be enrolled in the TU Delft Graduate School. The TU Delft Graduate School provides an inspiring research environment with an excellent team of supervisors, academic staff and a mentor. The Doctoral Education Programme is aimed at developing your transferable, discipline-related and research skills.