Participate in Development of a Systems Pharmacology Model Competition 2021 and Win USD 75000

Studying the pharmacological effects of drugs injected into the human eye is difficult because traditional sampling methods are invasive. Therefore, the Seeker desires a computational model that accurately simulates the systems pharmacology of an administered drug. This is a Reduction to Practice Challenge that requires written documentation, output from the proposed algorithm, and submission of the source code and/or an executable for validation, if requested by the Seeker.

Novartis is launching a Challenge for a recently introduced drug in the market that is linked with post-marketing adverse event case reports following administration of the drug in the human eye. A small number of patients experienced adverse events termed as “retinal vasculitis” and/or “retinal vascular occlusion” that may result in severe vision loss and/or decreased visual acuity. To understand these phenomena, the Seeker desires a systems pharmacology model that takes into account interactions between the drug, its target, and the ocular inflammatory process