March 12, 2019.
Advancing Gene Editing Technologies and Tools for Cystic Fibrosis: Research Grant
As an outcome of a CF gene editing workshop held over the summer, the Cystic Fibrosis Foundation announces a Request for Applications (RFA) to identify and support highly meritorious proposals in gene editing that offer potential to repair or circumvent CFTR mutations in individuals with CF.
There is still an unmet need for patients with CFTR mutations that do not yield sufficient quantities of protein for pharmacological correction. To treat all patients with cystic fibrosis, it will be necessary to correct variants that block protein synthesis (i.e. premature stop codon mutations, splice mutations, insertion/deletion mutations etc.), Gene repair strategies, as well as overcoming hurdles of poor delivery and cellular penetration, are issues that need to be addressed.
Opportunity Focus Areas: Research Applications will be evaluated on the following:
• RFA response, relevant to one or more of the following priority areas:
- Edit the development of the platform
- Develop the animal model, cells and / or organic species to release the test
- Animal model testing
- Development of delivery or testing system
- Safety / adverse events of editing
- Immune responses
EGYPT, SYRIA, IRAQ, PALESTINE, JORDAN, LEBANON, TUNISIA, ALGERIA, MOROCCO, SUDAN, LIBYA, SAUDI ARABIA, EMIRATES, KUWAIT, QATAR, BAHRAIN, OMAN, YEMEN, SOMALIA, DJIBOUTI, MAURITANIA, TURKEY, IRAN, CYPRUS, COMOROS, & OTHER COUNTRIES ARE NOT FROM THE MIDDLE EAST AND NORTH AFRICA.
Up to $200,000 per year plus 8% indirect costs for up to 3 years.
- U.S. residents and applicants from outside the U.S. are welcome to apply.
- International applicants and institutions are required to submit additional information in accordance with U.S. anti-terrorism restrictions.
- Applicants must be independent investigators:
o Must be a M.D., Ph.D. or dual M.D., Ph.D. and must be a well-established scientist.
o Must demonstrate a track record of discovery, investigation, and external funding resulting
in long-term commitment of salary, personnel and research resources.
o Candidates who are postdoctoral fellows should apply to the Advancing Gene Editing
Technologies and Tools for Cystic Fibrosis Postdoctoral Fellowship program.
- • Funding of up to US$200,000 per year, plus eight percent (8%) indirect costs may be requested for
up to three (3) years.
• Awards may be approved for up to a three-year period. Funding for Year 2 and Year 3 is contingent
upon submission and approval of a renewal progress report and the availability of funds.
First Step: Applications must be submitted online at proposalCENTRAL by 5 p.m. ET.
Second Step: Create an account Here.
Third Step: Upload all your documents Here Face Page which includes:
Applicant/PI information (online).
Complete Institution and PI Contact Information, including correct mailing address (online).
Research Plan, Supporting Documents and Appendices:
Abstracts ~ Summary of Relevance ~ Responsiveness – (complete online).
Budget Detail for each year – (upload).
Budget Justification for each year – (upload).
Research Plan – (upload).
Collaborative Program description – (upload).
Letter(s) of Support for Collaborative Investigators – (upload as PDFs).
Letter(s) of Support for Investigators New to CF Research – (upload as PDFs).
Verification of Applicant Institution’s Tax Status – (upload).
Appendices (upload as PDFs, if applicable).
Know more about this opportunity:
To learn how to write CV, Essays, Personal statement, and know about recommendation letters click here:
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This Scholarship Published by:
“Lubna Albadawi/ Syria “
Reviewed by” Soueilem Mohamed Lemine / Mauritania ”
MARJ3 Scholarships team